Eiji Hara Selected Research

Cyclin-Dependent Kinase Inhibitor p16

4/2015	Ablation of the p16(INK4a) tumour suppressor reverses ageing phenotypes of klotho mice.
10/2011	E2FBP1 antagonizes the p16(INK4A)-Rb tumor suppressor machinery for growth suppression and cellular senescence by regulating promyelocytic leukemia protein stability.
11/2010	Intrinsic cooperation between p16INK4a and p21Waf1/Cip1 in the onset of cellular senescence and tumor suppression in vivo.
1/2010	Real-time in vivo imaging of p16gene expression: a new approach to study senescence stress signaling in living animals.
8/2009	Real-time in vivo imaging of p16Ink4a reveals cross talk with p53.
11/2006	Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence.
5/2006	The expression of p16INK4a tumor suppressor is upregulated by human cytomegalovirus infection and required for optimal viral replication.
9/2005	Hepatocyte growth factor induces redistribution of p21(CIP1) and p27(KIP1) through ERK-dependent p16(INK4a) up-regulation, leading to cell cycle arrest at G1 in HepG2 hepatoma cells.

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Eiji Hara Research Topics

Disease

16	Neoplasms (Cancer) 02/2022 - 11/2002
5	Obesity 01/2022 - 07/2013
3	Carcinogenesis 02/2022 - 11/2010
3	Retinoblastoma (Glioblastoma, Retinal) 11/2006 - 07/2003
2	Hepatocellular Carcinoma (Hepatoma) 01/2022 - 09/2005
2	Inflammation (Inflammations) 11/2021 - 05/2013
2	Neoplasm Metastasis (Metastasis) 03/2016 - 03/2015
1	Hepatic Encephalopathy 01/2022
1	Colorectal Neoplasms (Colorectal Cancer) 01/2021
1	Bites and Stings (Sting) 01/2018
1	Non-alcoholic Fatty Liver Disease 01/2017
1	Lung Neoplasms (Lung Cancer) 03/2015
1	Carcinoma (Carcinomatosis) 03/2015
1	Adenocarcinoma of Lung 03/2015
1	Wounds and Injuries (Trauma) 12/2014
1	Mikulicz' Disease 01/2012
1	Ataxia Telangiectasia (Louis Bar Syndrome) 06/2009
1	Warts (Wart) 11/2006
1	Infections 05/2006

Drug/Important Bio-Agent (IBA)

8	Cyclin-Dependent Kinase Inhibitor p16IBA 04/2015 - 09/2005
3	Deoxycholic Acid (Sodium Deoxycholate)IBA 01/2017 - 07/2013
3	Proteins (Proteins, Gene)FDA Link 07/2014 - 02/2005
3	Cyclin-Dependent Kinases (cdk Proteins)IBA 11/2006 - 11/2002
2	DNA (Deoxyribonucleic Acid)IBA 01/2021 - 01/2018
2	Bile Acids and Salts (Bile Acids)IBA 01/2015 - 04/2014
2	Phosphotransferases (Kinase)IBA 06/2009 - 11/2006
2	Tumor Suppressor Proteins (Proteins, Tumor Suppressor)IBA 08/2004 - 07/2003
1	Rifaximin (L 105)FDA Link 01/2022
1	Interleukin-33IBA 01/2022
1	Biological ProductsIBA 01/2022
1	Dietary Fiber FDA Link 11/2021
1	Volatile Fatty AcidsIBA 11/2021
1	Butyrates (Butyrate)IBA 01/2021
1	Untranslated RNA (Noncoding RNA)IBA 01/2021
1	InterferonsIBA 01/2018
1	lipoteichoic acidIBA 01/2017
1	Dinoprostone (PGE2)FDA Link 01/2017
1	Ephrin-A1 (Ephrin A1)IBA 01/2017
1	Toll-Like Receptor 2IBA 01/2017
1	17- (dimethylaminoethylamino)- 17- demethoxygeldanamycinIBA 03/2016
1	Diphosphonates (Bisphosphonates)IBA 03/2016
1	LuciferasesIBA 03/2015
1	Pharmaceutical PreparationsIBA 03/2015
1	CrizotinibIBA 03/2015
1	alectinibIBA 03/2015
1	platelet-derived growth factor AIBA 12/2014
1	Platelet-Derived Growth FactorIBA 12/2014
1	A-Form DNA (A-DNA)IBA 04/2014
1	CytokinesIBA 05/2013
1	ChemokinesIBA 05/2013
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 05/2013
1	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2012
1	Promyelocytic Leukemia ProteinIBA 10/2011
1	anthraceneIBA 11/2010
1	Acetates (Acetic Acid Esters)FDA Link 11/2010
1	Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA 09/2005
1	Oncogene Proteins (Oncogene Protein)IBA 07/2003

Therapy/Procedure

1	Therapeutics 02/2022